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KMID : 0376219790160010027
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Chonnam Medical Journal
1979 Volume.16 No. 1 p.27 ~ p.36
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Synergism of Sulbenicillin with Gentamicin or Amikacin against Pseudomonas aeruginosa Isolates
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Abstract
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The in vitro effect of sulbenicillin(SB) on the inhibitory activity of gentamicin (GM) and amikacin(AK) against 54 strains of Pseudomonas aeruginosa isolated from patients of Kwangju area was examined by the checkerboard agar dilution technique. Synergism here is defined as that the FICI value must be less than 0.5 and the line in isobologram curved downward.
SB had a synergistic effect on the inhibitory activity of each aminoglycoside antibiotic against 24 strains(44.4%). - Among the remaining 30 strains, the number of isolates responded to the synergistic effect by SB-GM combination was 18(33.3%) while only 5 strains(9.3%) responded to the effect by SB-AK. Seven strains(13 % ), however, showed a negative response to both combinations.
Fisher´s immunotyping analysis revealed the predominant types were immunotype 2, 3, 7, and 1 in the order of frequencies. No particular relationship was found between the immunotype and drug-resistance. It was noteworthy, however, that 3 out of 4 strains resistant to AK belonged to immunotype 3.
Addition of SB in the amount of 1/2 MIC to the medium containing various doses of GM or AK brought about a significant alteration in the MIC of each antibiotic to the organism inoculated, the distribution of the MICs ranging from 0.16mg/ml to 5 mg / ml even among the strains of originally identical MIC group.
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